Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_R3_selected Exclusive	tier2_gs	8.69e-01	6.91e-01	6.50e-01	3.77e-02
tier2_gs Exclusive	EA_R3_selected	1.86e-01	4.56e-01	1.02e-03	3.92e-01
EA_R3_selected Exclusive	tier2_gs Exclusive	9.11e-01	8.66e-01	9.24e-01	9.04e-02
tier2_gs Exclusive	EA_R3_selected Exclusive	3.12e-01	5.58e-01	2.98e-03	4.38e-01
EA_R3_selected Exclusive	Overlap	9.90e-02	1.98e-01	3.37e-01	2.57e-01
tier2_gs Exclusive	Overlap	1.98e-02	2.38e-01	7.33e-01	9.70e-01
Overlap	Exclusives	7.76e-01	6.27e-01	2.47e-06	1.53e-01



Evaluating how well EA_R3_selected genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_R3_selected Exclusive	tier2_gs	0.62	-0.13	0.25	0.65	2.73
tier2_gs Exclusive	EA_R3_selected	0.49	-0.99	-0.98	-0.47	-0.41
EA_R3_selected Exclusive	tier2_gs Exclusive	0.61	-0.12	0.23	0.30	2.48
tier2_gs Exclusive	EA_R3_selected Exclusive	0.49	-0.85	-0.90	-0.71	-0.35
EA_R3_selected Exclusive	Overlap	0.88	2.05	1.54	1.26	1.37
tier2_gs Exclusive	Overlap	0.48	-2.31	-1.62	-0.90	-0.05
Overlap	Exclusives	0.53	0.33	0.75	0.50	1.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_R3_selected Exclusive	tier2_gs	0.00	-0.72	-0.41	-0.13	1.48
tier2_gs Exclusive	EA_R3_selected	0.01	3.80	8.87	10.00	10.38
EA_R3_selected Exclusive	tier2_gs Exclusive	0.00	-0.66	-0.23	-0.36	1.43
tier2_gs Exclusive	EA_R3_selected Exclusive	0.01	4.82	7.61	10.88	9.63
EA_R3_selected Exclusive	Overlap	0.00	1.70	2.06	0.32	0.07
tier2_gs Exclusive	Overlap	0.00	-0.62	-0.64	-0.32	-0.20
Overlap	Exclusives	0.01	0.13	0.33	0.30	0.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_R3_selected Exclusive	143	142	CHURC1-FNTB
tier2_gs Exclusive	45	42	IGH;TNSF12;TNSF13
Overlap	1	1