Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_R4_selected2 Exclusive	EA_R3_selected	5.25e-01	5.48e-01	6.44e-01	5.70e-01
EA_R3_selected Exclusive	EA_R4_selected2	8.72e-01	8.04e-01	9.35e-01	7.38e-01
EA_R4_selected2 Exclusive	EA_R3_selected Exclusive	6.80e-01	9.27e-01	7.11e-01	7.59e-01
EA_R3_selected Exclusive	EA_R4_selected2 Exclusive	7.95e-01	4.12e-01	5.51e-01	4.87e-01
EA_R4_selected2 Exclusive	Overlap	3.10e-01	2.02e-01	3.77e-01	2.29e-01
EA_R3_selected Exclusive	Overlap	4.56e-01	5.19e-01	4.41e-01	4.33e-01
Overlap	Exclusives	8.80e-01	4.76e-01	5.44e-01	9.99e-02



Evaluating how well EA_R4_selected2 genes are linked to EA_R3_selected genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_R4_selected2 Exclusive	EA_R3_selected	0.49	-0.72	-0.93	-0.53	-0.53
EA_R3_selected Exclusive	EA_R4_selected2	0.50	-0.13	-0.04	0.11	-0.03
EA_R4_selected2 Exclusive	EA_R3_selected Exclusive	0.49	-0.48	-0.45	-0.31	-0.27
EA_R3_selected Exclusive	EA_R4_selected2 Exclusive	0.49	-0.04	-0.50	-0.32	-0.20
EA_R4_selected2 Exclusive	Overlap	0.44	-0.99	-1.32	-0.75	-0.92
EA_R3_selected Exclusive	Overlap	0.56	0.72	0.76	0.77	0.72
Overlap	Exclusives	0.53	0.84	1.03	1.51	1.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_R4_selected2 Exclusive	EA_R3_selected	0.01	-0.40	-0.59	-0.06	-0.55
EA_R3_selected Exclusive	EA_R4_selected2	0.01	-0.36	-0.16	-0.17	-0.30
EA_R4_selected2 Exclusive	EA_R3_selected Exclusive	0.01	-0.53	-0.56	-0.52	-0.81
EA_R3_selected Exclusive	EA_R4_selected2 Exclusive	0.00	-0.49	-0.39	-0.86	-0.45
EA_R4_selected2 Exclusive	Overlap	0.00	3.37	0.91	3.72	0.54
EA_R3_selected Exclusive	Overlap	0.00	0.62	0.87	1.06	0.84
Overlap	Exclusives	0.01	0.70	0.63	0.94	0.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_R4_selected2 Exclusive	99	98	EDDM13
EA_R3_selected Exclusive	127	127	
Overlap	17	16	CHURC1-FNTB