Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma Regulomescore_R3 Exclusive	SigmaBinary Regulome_R3	2.56e-01	4.87e-01	4.64e-01	6.06e-02
SigmaBinary Regulome_R3 Exclusive	Sigma Regulomescore_R3	4.54e-01	8.97e-01	5.88e-01	2.68e-01
Sigma Regulomescore_R3 Exclusive	SigmaBinary Regulome_R3 Exclusive	3.82e-01	6.58e-01	6.03e-01	4.26e-01
SigmaBinary Regulome_R3 Exclusive	Sigma Regulomescore_R3 Exclusive	1.67e-01	2.43e-01	2.09e-01	2.27e-01
Sigma Regulomescore_R3 Exclusive	Overlap	4.84e-01	4.63e-01	6.97e-01	3.03e-02
SigmaBinary Regulome_R3 Exclusive	Overlap	7.55e-01	8.69e-01	8.70e-01	2.07e-01
Overlap	Exclusives	5.71e-01	5.35e-01	4.01e-01	8.16e-01



Evaluating how well Sigma Regulomescore_R3 genes are linked to SigmaBinary Regulome_R3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma Regulomescore_R3 Exclusive	SigmaBinary Regulome_R3	0.57	1.40	1.42	1.47	3.04
SigmaBinary Regulome_R3 Exclusive	Sigma Regulomescore_R3	0.54	1.07	0.45	0.66	1.95
Sigma Regulomescore_R3 Exclusive	SigmaBinary Regulome_R3 Exclusive	0.57	1.66	1.35	1.94	1.57
SigmaBinary Regulome_R3 Exclusive	Sigma Regulomescore_R3 Exclusive	0.53	1.13	1.14	1.14	0.54
Sigma Regulomescore_R3 Exclusive	Overlap	0.57	0.86	0.65	0.88	2.76
SigmaBinary Regulome_R3 Exclusive	Overlap	0.55	0.96	0.26	0.22	1.70
Overlap	Exclusives	0.51	0.39	1.10	0.56	0.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma Regulomescore_R3 Exclusive	SigmaBinary Regulome_R3	0.01	3.48	3.87	3.02	2.67
SigmaBinary Regulome_R3 Exclusive	Sigma Regulomescore_R3	0.02	11.85	10.43	5.85	12.19
Sigma Regulomescore_R3 Exclusive	SigmaBinary Regulome_R3 Exclusive	0.01	11.06	9.51	6.43	8.76
SigmaBinary Regulome_R3 Exclusive	Sigma Regulomescore_R3 Exclusive	0.03	65.33	107.77	81.33	53.39
Sigma Regulomescore_R3 Exclusive	Overlap	0.01	0.76	0.85	0.82	1.05
SigmaBinary Regulome_R3 Exclusive	Overlap	0.01	0.47	-0.37	-0.23	0.39
Overlap	Exclusives	0.00	0.29	0.96	0.20	0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma Regulomescore_R3 Exclusive	33	31	2-Mar;CLEC20A
SigmaBinary Regulome_R3 Exclusive	49	45	45353.0000;AL845331.2;C13orf46;March9
Overlap	119	114	AC233992.2;MARCOL;AC010197.2;SPECC1L-ADORA2A;CCDC187