Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_SigmaEA_R2_122 Exclusive	Tier2_gs	7.81e-03	4.00e-03	3.61e-04	1.45e-05
Tier2_gs Exclusive	Combined_SigmaEA_R2_122	1.81e-01	5.82e-02	1.73e-04	2.44e-03
Combined_SigmaEA_R2_122 Exclusive	Tier2_gs Exclusive	2.07e-02	9.23e-03	4.01e-04	6.86e-05
Tier2_gs Exclusive	Combined_SigmaEA_R2_122 Exclusive	1.28e-01	8.26e-02	2.91e-04	3.44e-03
Combined_SigmaEA_R2_122 Exclusive	Overlap	5.94e-02	1.19e-01	3.96e-02	7.92e-02
Tier2_gs Exclusive	Overlap	2.77e-01	4.16e-01	1.98e-01	4.55e-01
Overlap	Exclusives	4.38e-03	2.44e-02	2.50e-09	2.82e-06



Evaluating how well Combined_SigmaEA_R2_122 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_SigmaEA_R2_122 Exclusive	Tier2_gs	0.68	1.86	2.86	2.46	3.89
Tier2_gs Exclusive	Combined_SigmaEA_R2_122	0.59	2.33	3.18	2.70	3.50
Combined_SigmaEA_R2_122 Exclusive	Tier2_gs Exclusive	0.68	2.13	2.39	2.44	3.99
Tier2_gs Exclusive	Combined_SigmaEA_R2_122 Exclusive	0.59	2.49	2.21	2.67	3.88
Combined_SigmaEA_R2_122 Exclusive	Overlap	0.96	1.60	1.56	1.83	1.67
Tier2_gs Exclusive	Overlap	0.84	1.34	1.16	1.20	1.05
Overlap	Exclusives	0.60	2.15	2.47	2.15	4.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_SigmaEA_R2_122 Exclusive	Tier2_gs	0.01	5.33	9.23	8.07	16.05
Tier2_gs Exclusive	Combined_SigmaEA_R2_122	0.01	5.89	9.15	8.30	5.78
Combined_SigmaEA_R2_122 Exclusive	Tier2_gs Exclusive	0.01	3.51	10.00	9.34	6.74
Tier2_gs Exclusive	Combined_SigmaEA_R2_122 Exclusive	0.01	7.41	6.68	7.25	10.99
Combined_SigmaEA_R2_122 Exclusive	Overlap	0.00	0.62	0.80	3.06	2.80
Tier2_gs Exclusive	Overlap	0.00	0.65	0.02	0.44	0.24
Overlap	Exclusives	0.01	3.25	3.23	2.48	6.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_SigmaEA_R2_122 Exclusive	121	120	RFPL2
Tier2_gs Exclusive	45	42	TNSF12;TNSF13;IGH
Overlap	1	1