Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_SigmaEA_R2_122	Tier3_gs	8.58e-01	7.33e-01	5.52e-01	7.51e-01
Tier3_gs	Combined_SigmaEA_R2_122	1.02e-01	3.03e-01	1.36e-01	2.56e-02



Evaluating how well Combined_SigmaEA_R2_122 genes are linked to Tier3_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_SigmaEA_R2_122	Tier3_gs	0.54	0.28	0.13	0.34	0.76
Tier3_gs	Combined_SigmaEA_R2_122	0.57	1.65	1.36	1.55	2.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_SigmaEA_R2_122	Tier3_gs	0.00	0.27	0.93	-0.07	0.14
Tier3_gs	Combined_SigmaEA_R2_122	0.01	0.88	0.33	0.32	0.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_SigmaEA_R2_122	122	121	RFPL2
Tier3_gs	25	23	AC074212.3;APT8B4