Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Male_SigmaEA_R2_82 Exclusive	TIER1_GS	1.00e-06	5.36e-07	9.65e-08	1.27e-08
TIER1_GS Exclusive	Male_SigmaEA_R2_82	5.14e-01	3.38e-01	1.95e-01	1.38e-01
Male_SigmaEA_R2_82 Exclusive	TIER1_GS Exclusive	6.50e-06	4.55e-06	1.02e-06	7.43e-07
TIER1_GS Exclusive	Male_SigmaEA_R2_82 Exclusive	8.08e-01	3.86e-01	2.87e-01	2.08e-01
Male_SigmaEA_R2_82 Exclusive	Overlap	6.61e-03	7.96e-02	3.68e-03	2.44e-04
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	7.09e-06	7.23e-06	4.21e-16	8.33e-07



Evaluating how well Male_SigmaEA_R2_82 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82 Exclusive	TIER1_GS	0.81	3.94	5.04	3.15	5.96
TIER1_GS Exclusive	Male_SigmaEA_R2_82	0.56	1.77	1.52	1.51	1.82
Male_SigmaEA_R2_82 Exclusive	TIER1_GS Exclusive	0.79	3.56	4.74	3.55	5.14
TIER1_GS Exclusive	Male_SigmaEA_R2_82 Exclusive	0.54	1.26	1.09	1.36	1.27
Male_SigmaEA_R2_82 Exclusive	Overlap	0.97	2.52	2.44	2.71	2.93
TIER1_GS Exclusive	Overlap	1.00	2.81	2.80	2.95	3.49
Overlap	Exclusives	0.65	3.74	5.86	3.39	6.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82 Exclusive	TIER1_GS	0.01	9.69	12.70	6.59	8.64
TIER1_GS Exclusive	Male_SigmaEA_R2_82	0.02	31.94	46.05	10.81	31.89
Male_SigmaEA_R2_82 Exclusive	TIER1_GS Exclusive	0.01	10.99	11.76	7.10	4.48
TIER1_GS Exclusive	Male_SigmaEA_R2_82 Exclusive	0.02	26.24	22.46	28.71	21.64
Male_SigmaEA_R2_82 Exclusive	Overlap	0.00	5.01	7.50	7.24	5.97
TIER1_GS Exclusive	Overlap	0.10	179.61	163.65	465.87	106.92
Overlap	Exclusives	0.09	87.83	151.64	40.95	148.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Male_SigmaEA_R2_82 Exclusive	79	79	
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3