Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Male_SigmaEA_R2_82 Exclusive	Tier2_gs	4.30e-01	3.56e-01	8.48e-02	1.79e-03
Tier2_gs Exclusive	Male_SigmaEA_R2_82	4.11e-01	9.96e-01	1.20e-01	8.78e-01
Male_SigmaEA_R2_82 Exclusive	Tier2_gs Exclusive	4.33e-01	4.15e-01	1.44e-01	6.68e-03
Tier2_gs Exclusive	Male_SigmaEA_R2_82 Exclusive	3.51e-01	9.93e-01	8.38e-02	9.57e-01
Male_SigmaEA_R2_82 Exclusive	Overlap	2.97e-01	3.96e-01	2.57e-01	4.36e-01
Tier2_gs Exclusive	Overlap	2.18e-01	4.16e-01	1.98e-01	3.96e-01
Overlap	Exclusives	1.52e-02	6.59e-02	3.97e-06	3.90e-04



Evaluating how well Male_SigmaEA_R2_82 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82 Exclusive	Tier2_gs	0.62	-0.31	0.39	0.71	2.81
Tier2_gs Exclusive	Male_SigmaEA_R2_82	0.52	-0.53	-0.07	0.41	0.76
Male_SigmaEA_R2_82 Exclusive	Tier2_gs Exclusive	0.61	-0.31	0.37	0.37	2.62
Tier2_gs Exclusive	Male_SigmaEA_R2_82 Exclusive	0.52	-0.56	0.09	0.34	0.63
Male_SigmaEA_R2_82 Exclusive	Overlap	0.81	1.15	0.82	1.16	0.95
Tier2_gs Exclusive	Overlap	0.84	1.40	0.97	1.42	1.10
Overlap	Exclusives	0.60	2.08	2.59	1.70	3.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82 Exclusive	Tier2_gs	0.01	1.90	2.79	3.25	0.78
Tier2_gs Exclusive	Male_SigmaEA_R2_82	0.01	5.09	5.84	3.59	7.19
Male_SigmaEA_R2_82 Exclusive	Tier2_gs Exclusive	0.01	2.92	3.63	2.51	5.81
Tier2_gs Exclusive	Male_SigmaEA_R2_82 Exclusive	0.01	8.33	8.30	3.28	3.96
Male_SigmaEA_R2_82 Exclusive	Overlap	0.00	0.22	-0.08	0.20	-0.10
Tier2_gs Exclusive	Overlap	0.00	1.23	-0.06	0.15	-0.10
Overlap	Exclusives	0.01	1.51	2.52	1.04	4.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Male_SigmaEA_R2_82 Exclusive	81	81	
Tier2_gs Exclusive	45	42	IGH;TNSF13;TNSF12
Overlap	1	1