Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Male_SigmaEA_R2_82	Tier3_gs	8.01e-01	8.70e-01	4.23e-01	3.38e-01
Tier3_gs	Male_SigmaEA_R2_82	1.48e-01	1.97e-01	8.52e-02	8.66e-02



Evaluating how well Male_SigmaEA_R2_82 genes are linked to Tier3_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82	Tier3_gs	0.56	0.66	0.31	1.01	1.04
Tier3_gs	Male_SigmaEA_R2_82	0.56	1.86	2.42	1.72	1.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82	Tier3_gs	0.00	0.19	0.16	0.95	0.35
Tier3_gs	Male_SigmaEA_R2_82	0.00	0.48	0.44	0.67	0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Male_SigmaEA_R2_82	82	82	
Tier3_gs	25	23	APT8B4;AC074212.3