Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Male_SigmaEA_R2_82 Tier3_gs 8.01e-01 8.70e-01 4.23e-01 3.38e-01 Tier3_gs Male_SigmaEA_R2_82 1.48e-01 1.97e-01 8.52e-02 8.66e-02 Evaluating how well Male_SigmaEA_R2_82 genes are linked to Tier3_gs genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Male_SigmaEA_R2_82 Tier3_gs 0.56 0.66 0.31 1.01 1.04 Tier3_gs Male_SigmaEA_R2_82 0.56 1.86 2.42 1.72 1.86 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Male_SigmaEA_R2_82 Tier3_gs 0.00 0.19 0.16 0.95 0.35 Tier3_gs Male_SigmaEA_R2_82 0.00 0.48 0.44 0.67 0.04 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Male_SigmaEA_R2_82 82 82 Tier3_gs 25 23 APT8B4;AC074212.3