Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Male_SigmaEA_R2_82	Ismael_14_AD	5.84e-01	4.59e-01	1.78e-01	1.20e-02
Ismael_14_AD	Male_SigmaEA_R2_82	6.38e-02	7.14e-01	8.25e-04	6.49e-01



Evaluating how well Male_SigmaEA_R2_82 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82	Ismael_14_AD	0.75	0.67	1.57	1.02	3.31
Ismael_14_AD	Male_SigmaEA_R2_82	0.52	0.39	0.39	0.69	0.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Male_SigmaEA_R2_82	Ismael_14_AD	0.00	1.21	2.17	1.28	2.83
Ismael_14_AD	Male_SigmaEA_R2_82	0.01	-0.02	0.46	1.66	0.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Male_SigmaEA_R2_82	82	82	
Ismael_14_AD	14	14