Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Female_SigmaEA_R2_69 Exclusive	TIER1_GS	4.00e-06	1.66e-06	1.00e-06	3.23e-07
TIER1_GS Exclusive	Female_SigmaEA_R2_69	2.60e-01	5.75e-01	2.74e-01	4.48e-01
Female_SigmaEA_R2_69 Exclusive	TIER1_GS Exclusive	7.83e-05	4.45e-06	1.38e-05	5.59e-06
TIER1_GS Exclusive	Female_SigmaEA_R2_69 Exclusive	2.38e-01	8.28e-01	5.90e-01	8.28e-01
Female_SigmaEA_R2_69 Exclusive	Overlap	2.49e-02	5.17e-01	1.87e-02	1.34e-02
TIER1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	5.40e-05	2.30e-06	9.71e-18	7.56e-08



Evaluating how well Female_SigmaEA_R2_69 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69 Exclusive	TIER1_GS	0.80	2.29	5.83	2.97	6.04
TIER1_GS Exclusive	Female_SigmaEA_R2_69	0.52	0.34	-0.04	0.32	0.42
Female_SigmaEA_R2_69 Exclusive	TIER1_GS Exclusive	0.79	2.13	5.48	2.65	5.22
TIER1_GS Exclusive	Female_SigmaEA_R2_69 Exclusive	0.50	0.03	-0.35	0.10	-0.01
Female_SigmaEA_R2_69 Exclusive	Overlap	0.97	1.72	1.58	2.22	1.99
TIER1_GS Exclusive	Overlap	1.00	2.50	2.13	2.16	2.51
Overlap	Exclusives	0.67	5.46	6.32	4.28	5.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69 Exclusive	TIER1_GS	0.01	6.73	24.32	8.79	13.79
TIER1_GS Exclusive	Female_SigmaEA_R2_69	0.02	30.89	37.59	11.77	32.32
Female_SigmaEA_R2_69 Exclusive	TIER1_GS Exclusive	0.01	6.08	24.61	8.54	1.94
TIER1_GS Exclusive	Female_SigmaEA_R2_69 Exclusive	0.02	27.67	17.77	9.49	29.38
Female_SigmaEA_R2_69 Exclusive	Overlap	0.00	5.63	2.65	5.92	3.61
TIER1_GS Exclusive	Overlap	0.05	109.90	108.26	193.01	208.80
Overlap	Exclusives	0.05	37.05	87.86	57.83	36.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Female_SigmaEA_R2_69 Exclusive	67	65	RFPL2;RAB6D
TIER1_GS Exclusive	29	28	MS4A
Overlap	2	2