Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Female_SigmaEA_R2_69	Tier2_gs	4.53e-01	5.38e-02	7.72e-02	3.83e-03
Tier2_gs	Female_SigmaEA_R2_69	4.30e-01	8.02e-01	2.00e-01	5.15e-01



Evaluating how well Female_SigmaEA_R2_69 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69	Tier2_gs	0.66	1.23	2.67	1.75	3.52
Tier2_gs	Female_SigmaEA_R2_69	0.53	0.82	0.24	0.49	0.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69	Tier2_gs	0.00	2.16	4.44	2.09	4.03
Tier2_gs	Female_SigmaEA_R2_69	0.02	9.82	16.06	18.98	23.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Female_SigmaEA_R2_69	69	67	RFPL2;RAB6D
Tier2_gs	46	43	TNSF13;IGH;TNSF12