Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Female_SigmaEA_R2_69	Tier3_gs	8.98e-01	9.39e-01	7.78e-01	6.61e-01
Tier3_gs	Female_SigmaEA_R2_69	7.77e-01	9.18e-01	6.73e-01	5.55e-01



Evaluating how well Female_SigmaEA_R2_69 genes are linked to Tier3_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69	Tier3_gs	0.52	0.05	-0.47	0.08	0.45
Tier3_gs	Female_SigmaEA_R2_69	0.52	0.56	0.41	0.69	0.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69	Tier3_gs	0.00	-0.55	-0.54	-0.14	-0.25
Tier3_gs	Female_SigmaEA_R2_69	0.00	-0.10	-0.37	0.12	0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Female_SigmaEA_R2_69	69	67	RAB6D;RFPL2
Tier3_gs	25	23	APT8B4;AC074212.3