Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Female_SigmaEA_R2_69	Ismael_14_AD	3.66e-04	1.59e-04	2.28e-04	1.46e-05
Ismael_14_AD	Female_SigmaEA_R2_69	3.18e-01	3.33e-01	1.37e-03	3.75e-01



Evaluating how well Female_SigmaEA_R2_69 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69	Ismael_14_AD	0.87	2.96	4.69	2.50	5.22
Ismael_14_AD	Female_SigmaEA_R2_69	0.55	2.27	1.78	1.57	1.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female_SigmaEA_R2_69	Ismael_14_AD	0.00	4.98	15.61	5.19	8.80
Ismael_14_AD	Female_SigmaEA_R2_69	0.01	5.89	4.62	4.29	1.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Female_SigmaEA_R2_69	69	67	RFPL2;RAB6D
Ismael_14_AD	14	14