Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JimRay_list Exclusive	Sigma_NIAGADS_R2_3_242	5.95e-02	5.30e-02	2.38e-03	6.54e-02
Sigma_NIAGADS_R2_3_242 Exclusive	JimRay_list	2.59e-02	1.13e-01	9.01e-02	2.32e-01
JimRay_list Exclusive	Sigma_NIAGADS_R2_3_242 Exclusive	5.59e-02	7.34e-02	8.31e-03	1.14e-01
Sigma_NIAGADS_R2_3_242 Exclusive	JimRay_list Exclusive	1.61e-02	1.50e-01	4.65e-02	5.30e-01
JimRay_list Exclusive	Overlap	5.30e-01	2.41e-01	8.01e-01	9.71e-02
Sigma_NIAGADS_R2_3_242 Exclusive	Overlap	7.04e-01	7.89e-01	7.89e-01	4.85e-01
Overlap	Exclusives	3.43e-02	1.13e-01	9.72e-13	5.92e-02



Evaluating how well JimRay_list genes are linked to Sigma_NIAGADS_R2_3_242 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JimRay_list Exclusive	Sigma_NIAGADS_R2_3_242	0.54	1.66	2.50	1.60	2.26
Sigma_NIAGADS_R2_3_242 Exclusive	JimRay_list	0.56	1.78	1.14	1.19	0.61
JimRay_list Exclusive	Sigma_NIAGADS_R2_3_242 Exclusive	0.54	1.59	2.15	1.62	1.85
Sigma_NIAGADS_R2_3_242 Exclusive	JimRay_list Exclusive	0.54	2.20	1.20	1.42	0.42
JimRay_list Exclusive	Overlap	0.80	2.03	1.57	1.60	1.66
Sigma_NIAGADS_R2_3_242 Exclusive	Overlap	0.65	-0.05	-0.10	0.22	1.11
Overlap	Exclusives	0.54	1.51	2.23	1.64	2.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JimRay_list Exclusive	Sigma_NIAGADS_R2_3_242	0.02	2.85	4.54	1.47	4.01
Sigma_NIAGADS_R2_3_242 Exclusive	JimRay_list	0.01	38.00	25.52	19.63	9.75
JimRay_list Exclusive	Sigma_NIAGADS_R2_3_242 Exclusive	0.02	2.25	3.96	2.04	2.50
Sigma_NIAGADS_R2_3_242 Exclusive	JimRay_list Exclusive	0.00	37.10	26.07	20.59	11.17
JimRay_list Exclusive	Overlap	0.00	4.89	3.36	3.92	1.84
Sigma_NIAGADS_R2_3_242 Exclusive	Overlap	0.00	16.42	15.00	15.81	5.86
Overlap	Exclusives	0.02	1.76	2.89	1.83	3.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JimRay_list Exclusive	11	11	
Sigma_NIAGADS_R2_3_242 Exclusive	238	237	RFPL2
Overlap	3	3