Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
183_R2NIAGADS Exclusive	14_JimRay	2.24e-02	3.99e-02	2.24e-02	1.21e-01
14_JimRay Exclusive	183_R2NIAGADS	4.87e-02	4.02e-02	5.94e-02	3.39e-02
183_R2NIAGADS Exclusive	14_JimRay Exclusive	3.26e-02	1.34e-01	2.92e-02	1.36e-01
14_JimRay Exclusive	183_R2NIAGADS Exclusive	5.28e-02	5.84e-02	6.39e-02	5.13e-02
183_R2NIAGADS Exclusive	Overlap	7.89e-01	7.89e-01	6.76e-01	3.57e-01
14_JimRay Exclusive	Overlap	4.67e-01	3.74e-01	6.58e-01	1.70e-01
Overlap	Exclusives	7.93e-02	3.32e-01	7.29e-09	9.88e-02



Evaluating how well 183_R2NIAGADS genes are linked to 14_JimRay genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
183_R2NIAGADS Exclusive	14_JimRay	0.62	2.48	1.73	1.52	1.17
14_JimRay Exclusive	183_R2NIAGADS	0.56	2.05	2.75	1.99	2.57
183_R2NIAGADS Exclusive	14_JimRay Exclusive	0.60	2.12	1.52	2.00	1.21
14_JimRay Exclusive	183_R2NIAGADS Exclusive	0.56	2.12	2.60	1.96	2.63
183_R2NIAGADS Exclusive	Overlap	0.69	0.35	0.48	0.66	0.98
14_JimRay Exclusive	Overlap	0.79	1.71	1.56	1.42	1.65
Overlap	Exclusives	0.56	1.49	2.21	1.73	2.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
183_R2NIAGADS Exclusive	14_JimRay	0.01	37.49	31.62	25.67	6.95
14_JimRay Exclusive	183_R2NIAGADS	0.01	3.19	5.45	2.95	3.37
183_R2NIAGADS Exclusive	14_JimRay Exclusive	0.01	4.71	29.95	32.09	10.68
14_JimRay Exclusive	183_R2NIAGADS Exclusive	0.01	2.81	5.41	2.56	2.56
183_R2NIAGADS Exclusive	Overlap	0.00	9.63	15.19	18.65	4.50
14_JimRay Exclusive	Overlap	0.00	3.50	4.97	1.34	3.85
Overlap	Exclusives	0.01	2.25	4.13	2.47	4.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
183_R2NIAGADS Exclusive	180	179	RFPL2
14_JimRay Exclusive	11	11	
Overlap	3	3