Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
143_R4_NIAGADS Exclusive	14_JimRay	1.65e-01	1.65e-01	6.72e-02	1.09e-01
14_JimRay Exclusive	143_R4_NIAGADS	3.63e-01	4.03e-01	1.52e-01	2.04e-01
143_R4_NIAGADS Exclusive	14_JimRay Exclusive	3.26e-01	2.99e-01	1.75e-01	2.31e-01
14_JimRay Exclusive	143_R4_NIAGADS Exclusive	4.16e-01	4.48e-01	1.25e-01	3.24e-01
143_R4_NIAGADS Exclusive	Overlap	3.96e-02	1.98e-02	1.98e-02	1.98e-02
14_JimRay Exclusive	Overlap	3.96e-02	1.98e-02	3.96e-02	3.96e-02
Overlap	Exclusives	2.37e-01	5.18e-02	5.09e-01	3.99e-02



Evaluating how well 143_R4_NIAGADS genes are linked to 14_JimRay genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_R4_NIAGADS Exclusive	14_JimRay	0.64	1.48	1.88	1.88	1.99
14_JimRay Exclusive	143_R4_NIAGADS	0.54	1.18	1.34	1.45	1.42
143_R4_NIAGADS Exclusive	14_JimRay Exclusive	0.62	0.85	1.45	1.54	1.53
14_JimRay Exclusive	143_R4_NIAGADS Exclusive	0.53	1.12	1.31	1.13	1.25
143_R4_NIAGADS Exclusive	Overlap	1.00	1.59	1.87	2.09	1.45
14_JimRay Exclusive	Overlap	0.99	1.84	1.76	1.70	1.58
Overlap	Exclusives	0.57	2.57	2.69	2.61	3.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
143_R4_NIAGADS Exclusive	14_JimRay	0.01	8.28	14.85	18.18	4.91
14_JimRay Exclusive	143_R4_NIAGADS	0.01	3.13	3.10	3.01	3.89
143_R4_NIAGADS Exclusive	14_JimRay Exclusive	0.00	3.29	12.72	6.93	10.34
14_JimRay Exclusive	143_R4_NIAGADS Exclusive	0.01	2.21	3.11	1.87	3.40
143_R4_NIAGADS Exclusive	Overlap	0.01	2.63	22.65	7.83	13.80
14_JimRay Exclusive	Overlap	0.00	4.98	7.84	2.70	5.21
Overlap	Exclusives	0.01	6.07	6.12	4.77	7.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
143_R4_NIAGADS Exclusive	142	140	EDDM13;CHURC1-FNTB
14_JimRay Exclusive	13	13	
Overlap	1	1