Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
201_LBD	14_JimRay	3.43e-01	1.78e-01	2.56e-01	1.88e-01
14_JimRay	201_LBD	2.72e-01	9.52e-01	5.70e-01	8.01e-01



Evaluating how well 201_LBD genes are linked to 14_JimRay genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
201_LBD	14_JimRay	0.62	1.25	1.55	1.53	1.97
14_JimRay	201_LBD	0.50	-0.19	-0.08	0.07	0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
201_LBD	14_JimRay	0.00	14.07	16.95	14.44	7.78
14_JimRay	201_LBD	0.02	4.33	8.62	6.01	6.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
201_LBD	201	201	
14_JimRay	14	14