Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
301_AD_UKB Exclusive	14_JimRay	2.24e-01	7.74e-02	1.03e-01	1.84e-01
14_JimRay Exclusive	301_AD_UKB	7.89e-01	7.86e-01	1.09e-01	5.23e-01
301_AD_UKB Exclusive	14_JimRay Exclusive	7.14e-01	5.62e-01	4.65e-01	6.26e-01
14_JimRay Exclusive	301_AD_UKB Exclusive	8.70e-01	8.83e-01	7.09e-01	5.42e-01
301_AD_UKB Exclusive	Overlap	1.48e-03	9.85e-05	9.85e-04	2.07e-03
14_JimRay Exclusive	Overlap	2.31e-01	2.18e-01	1.11e-01	1.74e-01
Overlap	Exclusives	1.86e-04	1.24e-03	1.73e-02	7.00e-04



Evaluating how well 301_AD_UKB genes are linked to 14_JimRay genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
301_AD_UKB Exclusive	14_JimRay	0.60	1.36	1.56	1.53	1.18
14_JimRay Exclusive	301_AD_UKB	0.52	0.40	0.75	0.61	0.91
301_AD_UKB Exclusive	14_JimRay Exclusive	0.54	0.41	0.04	0.49	0.50
14_JimRay Exclusive	301_AD_UKB Exclusive	0.51	0.21	0.38	0.25	0.83
301_AD_UKB Exclusive	Overlap	0.98	2.13	3.32	1.99	2.36
14_JimRay Exclusive	Overlap	0.74	0.80	1.17	1.06	1.41
Overlap	Exclusives	0.56	2.80	3.53	2.63	3.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
301_AD_UKB Exclusive	14_JimRay	0.00	5.20	5.37	5.51	3.41
14_JimRay Exclusive	301_AD_UKB	0.02	0.50	0.77	0.64	0.65
301_AD_UKB Exclusive	14_JimRay Exclusive	0.00	1.13	0.98	0.44	0.16
14_JimRay Exclusive	301_AD_UKB Exclusive	0.02	0.34	0.63	0.27	0.78
301_AD_UKB Exclusive	Overlap	0.00	6.89	33.51	7.28	0.77
14_JimRay Exclusive	Overlap	0.00	-0.23	-0.07	-0.14	-0.08
Overlap	Exclusives	0.02	4.93	4.18	3.54	5.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
301_AD_UKB Exclusive	299	297	GIMD1;INAFM2
14_JimRay Exclusive	12	12	
Overlap	2	2