Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
312_ADProxy_UKB Exclusive	14_JimRay	6.29e-01	6.02e-01	5.84e-01	6.52e-01
14_JimRay Exclusive	312_ADProxy_UKB	7.58e-01	8.54e-01	7.76e-01	8.02e-01
312_ADProxy_UKB Exclusive	14_JimRay Exclusive	9.88e-01	8.70e-01	9.43e-01	8.98e-01
14_JimRay Exclusive	312_ADProxy_UKB Exclusive	6.50e-01	9.20e-01	8.68e-01	7.73e-01
312_ADProxy_UKB Exclusive	Overlap	3.96e-02	1.98e-02	1.19e-01	1.19e-01
14_JimRay Exclusive	Overlap	3.96e-02	1.98e-02	3.96e-02	1.98e-02
Overlap	Exclusives	2.27e-04	2.02e-01	8.54e-03	1.10e-01



Evaluating how well 312_ADProxy_UKB genes are linked to 14_JimRay genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
312_ADProxy_UKB Exclusive	14_JimRay	0.56	1.12	0.63	1.10	0.86
14_JimRay Exclusive	312_ADProxy_UKB	0.52	0.22	0.39	0.52	1.00
312_ADProxy_UKB Exclusive	14_JimRay Exclusive	0.53	0.53	0.14	0.23	0.54
14_JimRay Exclusive	312_ADProxy_UKB Exclusive	0.51	-0.04	0.38	0.31	1.20
312_ADProxy_UKB Exclusive	Overlap	0.97	2.21	2.59	1.86	1.43
14_JimRay Exclusive	Overlap	0.99	1.82	1.85	2.34	1.62
Overlap	Exclusives	0.53	1.59	1.91	2.00	1.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
312_ADProxy_UKB Exclusive	14_JimRay	0.00	4.58	3.92	1.31	1.37
14_JimRay Exclusive	312_ADProxy_UKB	0.02	0.71	1.32	1.56	1.50
312_ADProxy_UKB Exclusive	14_JimRay Exclusive	0.00	1.84	0.95	1.66	0.96
14_JimRay Exclusive	312_ADProxy_UKB Exclusive	0.02	0.40	1.39	1.02	1.62
312_ADProxy_UKB Exclusive	Overlap	0.00	2.23	9.09	0.30	0.18
14_JimRay Exclusive	Overlap	0.00	3.52	9.93	3.16	8.22
Overlap	Exclusives	0.02	3.88	3.55	2.82	3.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
312_ADProxy_UKB Exclusive	311	302	8-Sep;TMEM265;TSPY1;SERPINA3;KDM5D;CHURC1-FNTB;NLGN4Y;AC010616.1;ATG9B
14_JimRay Exclusive	13	13	
Overlap	1	1