Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 136_NIAGADS_R2 Exclusive 14_JimRay 1.86e-01 4.43e-01 9.52e-02 1.93e-01 14_JimRay Exclusive 136_NIAGADS_R2 3.61e-02 1.99e-02 3.83e-02 1.69e-02 136_NIAGADS_R2 Exclusive 14_JimRay Exclusive 2.93e-01 5.77e-01 1.92e-01 4.26e-01 14_JimRay Exclusive 136_NIAGADS_R2 Exclusive 5.60e-02 3.89e-02 3.22e-02 1.34e-02 136_NIAGADS_R2 Exclusive Overlap 4.40e-01 2.81e-01 1.80e-01 2.73e-01 14_JimRay Exclusive Overlap 5.37e-01 2.45e-01 4.98e-01 4.21e-01 Overlap Exclusives 2.39e-02 3.16e-02 1.02e-04 1.04e-03 Evaluating how well 136_NIAGADS_R2 genes are linked to 14_JimRay genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 136_NIAGADS_R2 Exclusive 14_JimRay 0.63 2.34 1.49 1.62 1.55 14_JimRay Exclusive 136_NIAGADS_R2 0.58 2.21 3.14 2.01 3.32 136_NIAGADS_R2 Exclusive 14_JimRay Exclusive 0.59 1.56 0.89 1.44 1.00 14_JimRay Exclusive 136_NIAGADS_R2 Exclusive 0.58 2.14 2.72 2.31 3.41 136_NIAGADS_R2 Exclusive Overlap 0.82 1.59 1.66 1.83 1.53 14_JimRay Exclusive Overlap 0.79 1.63 1.52 1.39 1.26 Overlap Exclusives 0.59 1.91 3.73 2.46 4.27 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 136_NIAGADS_R2 Exclusive 14_JimRay 0.01 51.40 48.71 15.02 17.01 14_JimRay Exclusive 136_NIAGADS_R2 0.01 3.52 5.89 3.56 3.05 136_NIAGADS_R2 Exclusive 14_JimRay Exclusive 0.01 30.93 24.81 25.49 13.41 14_JimRay Exclusive 136_NIAGADS_R2 Exclusive 0.01 2.33 4.92 2.41 5.05 136_NIAGADS_R2 Exclusive Overlap 0.01 37.84 21.05 59.08 53.48 14_JimRay Exclusive Overlap 0.00 3.24 5.10 0.02 0.21 Overlap Exclusives 0.01 3.71 7.06 4.92 6.02 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 136_NIAGADS_R2 Exclusive 134 133 RFPL2 14_JimRay Exclusive 12 12 Overlap 2 2