Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome Exclusive	Germline	2.58e-03	2.04e-02	4.27e-08	3.26e-08
Germline Exclusive	Reactome	5.00e-03	8.82e-02	3.30e-13	5.60e-09
Reactome Exclusive	Germline Exclusive	4.12e-02	1.82e-01	4.70e-06	6.71e-07
Germline Exclusive	Reactome Exclusive	2.13e-02	2.10e-01	2.00e-13	9.00e-09
Reactome Exclusive	Overlap	4.36e-07	4.22e-04	4.36e-07	3.66e-05
Germline Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.86e-05	1.09e-08	2.88e-27	1.37e-28



Evaluating how well Reactome genes are linked to Germline genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome Exclusive	Germline	0.85	0.79	2.46	1.98	6.03
Germline Exclusive	Reactome	0.67	0.51	1.37	1.36	7.56
Reactome Exclusive	Germline Exclusive	0.83	0.16	1.40	1.45	5.99
Germline Exclusive	Reactome Exclusive	0.66	0.23	0.88	1.46	9.09
Reactome Exclusive	Overlap	0.99	2.63	2.60	2.36	2.83
Germline Exclusive	Overlap	1.00	3.67	2.67	2.50	3.17
Overlap	Exclusives	0.76	2.03	7.38	1.98	13.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome Exclusive	Germline	0.01	-1.23	5.62	2.17	15.94
Germline Exclusive	Reactome	0.02	3.46	7.86	6.73	17.50
Reactome Exclusive	Germline Exclusive	0.01	-1.34	2.20	0.45	10.18
Germline Exclusive	Reactome Exclusive	0.02	1.43	4.49	4.80	8.59
Reactome Exclusive	Overlap	0.01	12.36	21.42	37.72	53.84
Germline Exclusive	Overlap	0.05	333.97	77.33	146.08	207.21
Overlap	Exclusives	0.06	12.64	33.93	11.18	69.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome Exclusive	174	174	
Germline Exclusive	28	26	NSB1;BRP1
Overlap	3	3