Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Regulome_R4_selected2_rerun Exclusive Regulome_score_R3_selected 4.09e-01 6.30e-01 2.95e-01 1.08e-01 Regulome_score_R3_selected Exclusive Regulome_R4_selected2_rerun 5.14e-01 8.29e-01 2.71e-01 2.21e-01 Regulome_R4_selected2_rerun Exclusive Regulome_score_R3_selected Exclusive 3.81e-01 3.63e-01 4.31e-01 2.43e-01 Regulome_score_R3_selected Exclusive Regulome_R4_selected2_rerun Exclusive 4.58e-01 7.85e-01 4.27e-01 5.10e-01 Regulome_R4_selected2_rerun Exclusive Overlap 7.38e-01 5.70e-01 3.88e-01 1.59e-01 Regulome_score_R3_selected Exclusive Overlap 9.16e-01 6.04e-01 5.46e-01 1.08e-01 Overlap Exclusives 4.24e-01 8.04e-01 6.18e-04 7.91e-02 Evaluating how well Regulome_R4_selected2_rerun genes are linked to Regulome_score_R3_selected genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Regulome_R4_selected2_rerun Exclusive Regulome_score_R3_selected 0.55 1.17 0.59 1.14 2.13 Regulome_score_R3_selected Exclusive Regulome_R4_selected2_rerun 0.54 0.54 0.53 0.79 1.75 Regulome_R4_selected2_rerun Exclusive Regulome_score_R3_selected Exclusive 0.53 0.79 -0.08 0.71 1.41 Regulome_score_R3_selected Exclusive Regulome_R4_selected2_rerun Exclusive 0.53 0.26 0.27 0.65 1.20 Regulome_R4_selected2_rerun Exclusive Overlap 0.61 0.81 1.12 1.12 1.59 Regulome_score_R3_selected Exclusive Overlap 0.60 0.64 0.60 0.88 1.90 Overlap Exclusives 0.54 0.63 0.62 1.04 2.36 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Regulome_R4_selected2_rerun Exclusive Regulome_score_R3_selected 0.01 0.73 0.56 0.86 2.07 Regulome_score_R3_selected Exclusive Regulome_R4_selected2_rerun 0.01 0.77 0.71 0.70 1.52 Regulome_R4_selected2_rerun Exclusive Regulome_score_R3_selected Exclusive 0.01 0.08 -0.52 0.27 0.53 Regulome_score_R3_selected Exclusive Regulome_R4_selected2_rerun Exclusive 0.01 0.30 0.46 0.60 0.63 Regulome_R4_selected2_rerun Exclusive Overlap 0.00 4.00 5.36 5.69 4.58 Regulome_score_R3_selected Exclusive Overlap 0.00 0.65 1.26 0.64 0.97 Overlap Exclusives 0.02 1.85 1.40 1.90 2.80 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Regulome_R4_selected2_rerun Exclusive 160 153 AL451062.3;PRAMEF15;TNFSF12-TNFSF13;TMEM191C;AC005779.2;LINC02210-CRHR1;TAF11L13 Regulome_score_R3_selected Exclusive 128 121 AC233992.2;SPECC1L-ADORA2A;CLEC20A;AC010197.2;2-Mar;CCDC187;MARCOL Overlap 24 24