Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
103_sigma_AD	GS_tier2	4.11e-02	4.07e-02	2.60e-02	1.46e-04
GS_tier2	103_sigma_AD	3.89e-01	5.92e-01	4.39e-02	4.68e-01



Evaluating how well 103_sigma_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
103_sigma_AD	GS_tier2	0.69	2.15	2.71	2.23	4.62
GS_tier2	103_sigma_AD	0.53	-0.23	0.31	0.11	1.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
103_sigma_AD	GS_tier2	0.00	0.61	2.11	1.48	4.10
GS_tier2	103_sigma_AD	0.02	20.97	20.56	18.83	21.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
103_sigma_AD	103	103	
GS_tier2	46	43	IGH;TNSF12;TNSF13