Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
103_sigma_AD	Ismael_GS	3.10e-02	6.53e-02	1.48e-02	5.38e-04
Ismael_GS	103_sigma_AD	1.20e-01	8.86e-01	2.48e-03	8.23e-01



Evaluating how well 103_sigma_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
103_sigma_AD	Ismael_GS	0.79	1.65	2.15	1.58	3.56
Ismael_GS	103_sigma_AD	0.52	0.01	-0.38	-0.28	0.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
103_sigma_AD	Ismael_GS	0.00	1.21	1.48	0.98	1.37
Ismael_GS	103_sigma_AD	0.01	0.15	0.79	0.73	1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
103_sigma_AD	103	103	
Ismael_GS	14	14