Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
103_sigma_AD Exclusive	GWAS_GS	3.39e-02	6.97e-02	1.12e-02	2.86e-03
GWAS_GS Exclusive	103_sigma_AD	3.25e-01	8.47e-01	4.22e-01	8.97e-01
103_sigma_AD Exclusive	GWAS_GS Exclusive	3.64e-02	9.99e-02	2.06e-02	1.92e-03
GWAS_GS Exclusive	103_sigma_AD Exclusive	2.16e-01	8.63e-01	7.15e-01	9.96e-01
103_sigma_AD Exclusive	Overlap	2.59e-01	3.35e-01	3.95e-01	3.77e-01
GWAS_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	6.79e-04	2.13e-04	8.97e-09	2.43e-06



Evaluating how well 103_sigma_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
103_sigma_AD Exclusive	GWAS_GS	0.61	1.58	1.84	1.20	3.73
GWAS_GS Exclusive	103_sigma_AD	0.51	-0.62	-0.74	-0.61	0.42
103_sigma_AD Exclusive	GWAS_GS Exclusive	0.61	1.40	1.69	1.20	3.73
GWAS_GS Exclusive	103_sigma_AD Exclusive	0.50	-1.41	-0.78	-0.76	-0.10
103_sigma_AD Exclusive	Overlap	0.69	0.94	0.88	0.67	0.81
GWAS_GS Exclusive	Overlap	1.00	2.79	2.35	2.48	2.48
Overlap	Exclusives	0.62	2.21	4.47	3.04	5.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
103_sigma_AD Exclusive	GWAS_GS	0.01	1.06	0.80	0.75	2.10
GWAS_GS Exclusive	103_sigma_AD	0.01	17.20	15.83	11.97	7.51
103_sigma_AD Exclusive	GWAS_GS Exclusive	0.01	1.07	0.76	0.70	1.90
GWAS_GS Exclusive	103_sigma_AD Exclusive	0.01	0.98	2.51	2.13	2.42
103_sigma_AD Exclusive	Overlap	0.00	0.09	-0.19	-0.17	-0.16
GWAS_GS Exclusive	Overlap	0.15	2027.16	221.68	407.28	440.38
Overlap	Exclusives	0.05	21.05	54.35	33.83	60.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
103_sigma_AD Exclusive	101	101	
GWAS_GS Exclusive	107	102	SLC8A1-AS1;PCDH11Y;MIR302F;D21S2088E;LINC00158
Overlap	2	2