Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
156_EAML_AD Exclusive	GS_tier1	1.91e-02	1.40e-02	4.03e-03	4.77e-01
GS_tier1 Exclusive	156_EAML_AD	3.59e-02	9.71e-01	8.71e-01	1.69e-01
156_EAML_AD Exclusive	GS_tier1 Exclusive	4.50e-02	2.57e-02	1.23e-02	4.99e-01
GS_tier1 Exclusive	156_EAML_AD Exclusive	3.15e-02	8.47e-01	9.28e-01	5.86e-02
156_EAML_AD Exclusive	Overlap	2.41e-01	2.58e-01	1.51e-01	7.62e-01
GS_tier1 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	6.83e-03	7.56e-03	9.33e-10	1.13e-02



Evaluating how well 156_EAML_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD Exclusive	GS_tier1	0.48	-1.61	-3.22	-1.71	-0.50
GS_tier1 Exclusive	156_EAML_AD	0.47	-0.70	-0.34	-0.45	-1.43
156_EAML_AD Exclusive	GS_tier1 Exclusive	0.48	-1.27	-2.57	-1.85	-0.41
GS_tier1 Exclusive	156_EAML_AD Exclusive	0.45	-1.20	-0.83	-0.76	-1.96
156_EAML_AD Exclusive	Overlap	0.48	-1.21	-1.63	-1.40	-0.16
GS_tier1 Exclusive	Overlap	1.00	2.89	2.90	3.00	3.87
Overlap	Exclusives	0.54	3.32	2.92	2.43	1.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD Exclusive	GS_tier1	0.00	-0.55	-1.15	-0.73	-0.02
GS_tier1 Exclusive	156_EAML_AD	0.01	4.44	6.41	3.09	2.52
156_EAML_AD Exclusive	GS_tier1 Exclusive	0.00	-0.64	-1.09	-0.82	-0.32
GS_tier1 Exclusive	156_EAML_AD Exclusive	0.01	-0.73	-0.93	-0.73	-1.14
156_EAML_AD Exclusive	Overlap	0.00	0.32	-0.20	-0.25	0.21
GS_tier1 Exclusive	Overlap	0.18	499.66	232.81	571.46	1616.18
Overlap	Exclusives	0.05	55.90	68.53	27.67	53.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
156_EAML_AD Exclusive	152	150	C22orf46;INAFM2
GS_tier1 Exclusive	27	26	MS4A
Overlap	4	4