Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
156_EAML_AD	GS_tier2	5.78e-01	4.26e-01	9.03e-01	1.17e-02
GS_tier2	156_EAML_AD	1.30e-01	4.40e-01	4.76e-02	3.47e-02



Evaluating how well 156_EAML_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD	GS_tier2	0.64	1.12	1.52	1.05	3.79
GS_tier2	156_EAML_AD	0.46	-0.94	-0.46	-0.64	-1.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD	GS_tier2	0.00	1.65	1.00	0.70	2.29
GS_tier2	156_EAML_AD	0.02	5.47	15.83	7.36	11.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
156_EAML_AD	156	154	C22orf46;INAFM2
GS_tier2	46	43	TNSF12;IGH;TNSF13