Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
156_EAML_AD	Ismael_GS	4.05e-02	1.69e-01	1.86e-01	1.54e-03
Ismael_GS	156_EAML_AD	1.34e-02	3.76e-01	7.11e-04	3.88e-02



Evaluating how well 156_EAML_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD	Ismael_GS	0.80	1.71	2.71	1.30	3.67
Ismael_GS	156_EAML_AD	0.48	-0.53	0.06	0.47	-0.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD	Ismael_GS	0.00	3.42	4.11	0.99	4.14
Ismael_GS	156_EAML_AD	0.01	1.47	1.20	1.93	1.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
156_EAML_AD	156	154	INAFM2;C22orf46
Ismael_GS	14	14