Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
156_EAML_AD Exclusive	GWAS_GS	8.37e-01	7.88e-01	2.19e-01	4.05e-01
GWAS_GS Exclusive	156_EAML_AD	7.13e-02	4.02e-01	2.88e-01	4.82e-02
156_EAML_AD Exclusive	GWAS_GS Exclusive	7.01e-01	4.65e-01	5.01e-02	4.54e-01
GWAS_GS Exclusive	156_EAML_AD Exclusive	5.66e-02	3.47e-01	6.64e-01	1.96e-02
156_EAML_AD Exclusive	Overlap	2.73e-01	4.55e-01	6.14e-01	5.82e-02
GWAS_GS Exclusive	Overlap	1.79e-04	2.23e-03	9.68e-07	3.57e-06
Overlap	Exclusives	3.28e-04	2.82e-06	7.38e-20	6.77e-07



Evaluating how well 156_EAML_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD Exclusive	GWAS_GS	0.55	0.19	-0.33	-0.49	2.08
GWAS_GS Exclusive	156_EAML_AD	0.46	-1.13	-0.66	-0.72	-1.89
156_EAML_AD Exclusive	GWAS_GS Exclusive	0.54	-0.03	-0.94	-0.95	1.58
GWAS_GS Exclusive	156_EAML_AD Exclusive	0.44	-1.77	-1.12	-1.50	-2.62
156_EAML_AD Exclusive	Overlap	0.74	1.41	1.00	0.59	1.88
GWAS_GS Exclusive	Overlap	0.97	4.40	3.73	3.68	3.79
Overlap	Exclusives	0.59	5.52	6.10	4.84	4.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
156_EAML_AD Exclusive	GWAS_GS	0.01	1.25	1.03	0.64	0.89
GWAS_GS Exclusive	156_EAML_AD	0.01	14.09	13.48	4.79	6.25
156_EAML_AD Exclusive	GWAS_GS Exclusive	0.01	1.13	0.31	0.31	1.59
GWAS_GS Exclusive	156_EAML_AD Exclusive	0.01	0.52	1.41	0.33	-0.26
156_EAML_AD Exclusive	Overlap	0.00	1.58	0.55	-0.12	-0.04
GWAS_GS Exclusive	Overlap	0.08	151.60	31.33	249.97	155.58
Overlap	Exclusives	0.05	27.17	57.51	35.59	37.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
156_EAML_AD Exclusive	150	148	C22orf46;INAFM2
GWAS_GS Exclusive	103	98	MIR302F;LINC00158;PCDH11Y;SLC8A1-AS1;D21S2088E
Overlap	6	6