Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_Regulome_R4_unique	Sigma_EA_R4_unique	4.86e-01	2.99e-01	2.49e-01	5.54e-01
Sigma_EA_R4_unique	Sigma_Regulome_R4_unique	1.86e-01	3.94e-01	3.05e-01	3.18e-02



Evaluating how well Sigma_Regulome_R4_unique genes are linked to Sigma_EA_R4_unique genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_Regulome_R4_unique	Sigma_EA_R4_unique	0.52	0.85	1.25	0.88	0.96
Sigma_EA_R4_unique	Sigma_Regulome_R4_unique	0.56	1.97	1.35	1.61	2.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_Regulome_R4_unique	Sigma_EA_R4_unique	0.01	3.31	0.61	2.78	2.16
Sigma_EA_R4_unique	Sigma_Regulome_R4_unique	0.01	1.12	1.00	1.55	2.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_Regulome_R4_unique	175	168	AC005779.2;TMEM191C;TAF11L13;PRAMEF15;AL451062.3;LINC02210-CRHR1;TNFSF12-TNFSF13
Sigma_EA_R4_unique	107	105	CHURC1-FNTB;EDDM13