Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_Regulome_R4_unique	common_genes	1.01e-01	5.95e-02	6.52e-02	2.06e-01
common_genes	Sigma_Regulome_R4_unique	1.33e-01	3.84e-01	3.00e-02	1.91e-01



Evaluating how well Sigma_Regulome_R4_unique genes are linked to common_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_Regulome_R4_unique	common_genes	0.59	1.65	2.21	1.72	0.79
common_genes	Sigma_Regulome_R4_unique	0.54	0.60	0.59	0.48	1.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_Regulome_R4_unique	common_genes	0.00	4.08	8.18	7.46	2.77
common_genes	Sigma_Regulome_R4_unique	0.01	0.84	1.99	1.17	1.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_Regulome_R4_unique	175	168	LINC02210-CRHR1;AL451062.3;PRAMEF15;AC005779.2;TNFSF12-TNFSF13;TMEM191C;TAF11L13
common_genes	9	9