Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R4_unique	common_genes	9.54e-01	7.67e-01	7.45e-01	3.71e-01
common_genes	Sigma_EA_R4_unique	3.12e-01	3.38e-01	6.01e-01	2.36e-01



Evaluating how well Sigma_EA_R4_unique genes are linked to common_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4_unique	common_genes	0.43	0.16	-0.69	-0.55	-0.98
common_genes	Sigma_EA_R4_unique	0.53	0.03	1.19	1.09	1.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4_unique	common_genes	0.00	0.49	-0.37	-0.23	-0.12
common_genes	Sigma_EA_R4_unique	0.01	-0.36	0.59	0.24	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R4_unique	107	105	CHURC1-FNTB;EDDM13
common_genes	9	9