Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_Regulome_R4_unique Exclusive	TIER1_GS	5.62e-04	1.56e-04	6.44e-05	2.22e-06
TIER1_GS Exclusive	Sigma_Regulome_R4_unique	9.69e-02	9.78e-01	3.80e-01	4.65e-01
Sigma_Regulome_R4_unique Exclusive	TIER1_GS Exclusive	4.43e-03	1.20e-03	7.53e-04	9.24e-05
TIER1_GS Exclusive	Sigma_Regulome_R4_unique Exclusive	6.91e-02	1.00e+00	7.42e-01	5.33e-01
Sigma_Regulome_R4_unique Exclusive	Overlap	5.12e-02	8.78e-02	2.38e-02	8.03e-03
TIER1_GS Exclusive	Overlap	4.36e-07	2.61e-03	4.36e-07	9.58e-05
Overlap	Exclusives	7.03e-03	1.61e-02	5.76e-13	3.53e-03



Evaluating how well Sigma_Regulome_R4_unique genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_Regulome_R4_unique Exclusive	TIER1_GS	0.77	2.98	4.33	2.68	4.98
TIER1_GS Exclusive	Sigma_Regulome_R4_unique	0.54	0.27	0.36	0.29	1.64
Sigma_Regulome_R4_unique Exclusive	TIER1_GS Exclusive	0.75	2.39	4.26	2.62	4.56
TIER1_GS Exclusive	Sigma_Regulome_R4_unique Exclusive	0.53	-0.08	-0.04	-0.10	1.20
Sigma_Regulome_R4_unique Exclusive	Overlap	0.87	1.26	1.30	1.32	2.12
TIER1_GS Exclusive	Overlap	0.99	2.62	2.42	2.69	2.92
Overlap	Exclusives	0.59	2.31	2.88	2.36	4.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_Regulome_R4_unique Exclusive	TIER1_GS	0.00	2.91	6.43	4.08	3.61
TIER1_GS Exclusive	Sigma_Regulome_R4_unique	0.01	6.00	2.93	5.80	4.85
Sigma_Regulome_R4_unique Exclusive	TIER1_GS Exclusive	0.00	2.16	8.68	1.87	7.31
TIER1_GS Exclusive	Sigma_Regulome_R4_unique Exclusive	0.01	1.75	1.99	2.13	2.03
Sigma_Regulome_R4_unique Exclusive	Overlap	0.00	0.60	0.35	0.86	1.34
TIER1_GS Exclusive	Overlap	0.03	113.22	25.38	120.91	37.99
Overlap	Exclusives	0.05	45.02	62.71	41.26	73.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_Regulome_R4_unique Exclusive	172	165	TAF11L13;TNFSF12-TNFSF13;LINC02210-CRHR1;TMEM191C;AL451062.3;PRAMEF15;AC005779.2
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3