Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R4_unique Exclusive	TIER1_GS	3.23e-08	4.12e-09	5.75e-08	3.33e-10
TIER1_GS Exclusive	Sigma_EA_R4_unique	2.14e-02	9.94e-02	2.10e-03	7.30e-02
Sigma_EA_R4_unique Exclusive	TIER1_GS Exclusive	2.40e-07	8.77e-08	3.82e-07	3.76e-09
TIER1_GS Exclusive	Sigma_EA_R4_unique Exclusive	2.18e-02	1.35e-01	4.32e-03	6.71e-02
Sigma_EA_R4_unique Exclusive	Overlap	5.91e-04	9.85e-05	5.91e-04	3.55e-03
TIER1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	6.01e-06	5.02e-06	1.18e-08	3.56e-06



Evaluating how well Sigma_EA_R4_unique genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4_unique Exclusive	TIER1_GS	0.84	3.45	6.56	3.56	5.91
TIER1_GS Exclusive	Sigma_EA_R4_unique	0.52	0.52	0.72	0.78	0.71
Sigma_EA_R4_unique Exclusive	TIER1_GS Exclusive	0.83	4.14	5.70	3.79	5.63
TIER1_GS Exclusive	Sigma_EA_R4_unique Exclusive	0.51	0.38	0.36	0.39	0.56
Sigma_EA_R4_unique Exclusive	Overlap	0.98	2.88	3.07	2.28	2.41
TIER1_GS Exclusive	Overlap	1.00	2.65	2.26	3.04	2.62
Overlap	Exclusives	0.64	2.63	5.72	3.31	5.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4_unique Exclusive	TIER1_GS	0.01	11.12	11.27	12.51	17.92
TIER1_GS Exclusive	Sigma_EA_R4_unique	0.02	24.74	34.43	25.77	31.98
Sigma_EA_R4_unique Exclusive	TIER1_GS Exclusive	0.01	10.89	9.74	4.54	5.81
TIER1_GS Exclusive	Sigma_EA_R4_unique Exclusive	0.02	17.07	16.18	18.35	20.45
Sigma_EA_R4_unique Exclusive	Overlap	0.00	3.86	34.62	16.04	1.86
TIER1_GS Exclusive	Overlap	0.12	384.45	124.19	571.55	439.35
Overlap	Exclusives	0.08	49.69	99.11	66.90	105.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R4_unique Exclusive	105	103	EDDM13;CHURC1-FNTB
TIER1_GS Exclusive	29	28	MS4A
Overlap	2	2