Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
control_all_variants Exclusive	TIER1_GS	1.95e-01	5.80e-02	2.61e-02	7.61e-04
TIER1_GS Exclusive	control_all_variants	1.63e-01	7.45e-01	2.85e-01	2.53e-01
control_all_variants Exclusive	TIER1_GS Exclusive	7.96e-02	2.40e-02	1.85e-02	3.37e-03
TIER1_GS Exclusive	control_all_variants Exclusive	1.32e-01	6.79e-01	2.13e-01	4.50e-01
control_all_variants Exclusive	Overlap	5.94e-01	6.25e-01	9.47e-01	8.70e-02
TIER1_GS Exclusive	Overlap	4.17e-10	2.42e-06	4.47e-11	1.16e-07
Overlap	Exclusives	3.06e-02	4.88e-02	5.17e-18	1.54e-02



Evaluating how well control_all_variants genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
control_all_variants Exclusive	TIER1_GS	0.71	1.41	3.15	1.74	3.67
TIER1_GS Exclusive	control_all_variants	0.53	0.35	0.30	0.53	1.32
control_all_variants Exclusive	TIER1_GS Exclusive	0.70	1.77	3.37	1.79	3.62
TIER1_GS Exclusive	control_all_variants Exclusive	0.52	-0.09	-0.03	0.35	0.62
control_all_variants Exclusive	Overlap	0.74	-0.33	-0.07	0.21	1.95
TIER1_GS Exclusive	Overlap	0.99	3.14	3.09	3.36	3.92
Overlap	Exclusives	0.57	2.98	2.50	1.93	3.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
control_all_variants Exclusive	TIER1_GS	0.00	0.46	3.01	1.30	3.52
TIER1_GS Exclusive	control_all_variants	0.01	5.48	5.09	4.66	5.94
control_all_variants Exclusive	TIER1_GS Exclusive	0.00	1.03	3.14	0.51	0.68
TIER1_GS Exclusive	control_all_variants Exclusive	0.01	1.26	0.78	1.42	1.66
control_all_variants Exclusive	Overlap	0.00	0.07	1.77	1.39	0.92
TIER1_GS Exclusive	Overlap	0.04	131.29	52.85	177.33	111.08
Overlap	Exclusives	0.05	44.55	55.45	38.36	34.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
control_all_variants Exclusive	181	174	PRAMEF15;LINC02210-CRHR1;ZNF511-PRAP1;AC005779.2;MRPL23;Gene_name;TNFSF12-TNFSF13
TIER1_GS Exclusive	26	25	MS4A
Overlap	5	5