Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) control_all_variants Exclusive Regulome-scores 3.57e-02 5.26e-02 1.09e-01 4.48e-03 Regulome-scores Exclusive control_all_variants 5.31e-01 6.76e-01 5.04e-01 5.56e-01 control_all_variants Exclusive Regulome-scores Exclusive 9.48e-01 6.44e-01 9.75e-01 7.49e-01 Regulome-scores Exclusive control_all_variants Exclusive 9.60e-01 9.84e-01 8.77e-01 9.84e-01 control_all_variants Exclusive Overlap 3.05e-02 9.30e-02 1.05e-01 6.27e-03 Regulome-scores Exclusive Overlap 6.44e-01 6.12e-01 5.59e-01 5.97e-01 Overlap Exclusives 4.78e-01 1.32e-01 1.74e-01 2.99e-01 Evaluating how well control_all_variants genes are linked to Regulome-scores genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) control_all_variants Exclusive Regulome-scores 0.57 2.66 2.53 2.89 3.37 Regulome-scores Exclusive control_all_variants 0.53 0.48 0.29 0.68 1.38 control_all_variants Exclusive Regulome-scores Exclusive 0.54 0.67 0.74 0.88 0.92 Regulome-scores Exclusive control_all_variants Exclusive 0.51 0.64 0.36 0.78 0.11 control_all_variants Exclusive Overlap 0.58 2.87 2.33 2.57 3.18 Regulome-scores Exclusive Overlap 0.54 0.22 0.49 0.54 1.24 Overlap Exclusives 0.55 2.21 2.27 1.95 1.82 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) control_all_variants Exclusive Regulome-scores 0.01 2.71 2.22 1.94 3.15 Regulome-scores Exclusive control_all_variants 0.01 2.00 0.82 0.93 2.45 control_all_variants Exclusive Regulome-scores Exclusive 0.00 0.25 0.33 0.43 0.28 Regulome-scores Exclusive control_all_variants Exclusive 0.00 0.30 -0.14 0.09 0.23 control_all_variants Exclusive Overlap 0.01 3.04 1.60 1.66 3.02 Regulome-scores Exclusive Overlap 0.01 1.37 1.76 1.46 1.15 Overlap Exclusives 0.01 1.31 3.31 3.48 3.08 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes control_all_variants Exclusive 43 41 MRPL23;ZNF511-PRAP1 Regulome-scores Exclusive 42 39 AL451062.3;TMEM191C;TAF11L13 Overlap 142 138 AC005779.2;LINC02210-CRHR1;TNFSF12-TNFSF13;PRAMEF15