Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
28_EAML_AD Exclusive	GS_tier1	9.43e-03	9.79e-03	9.38e-04	1.22e-04
GS_tier1 Exclusive	28_EAML_AD	7.42e-03	1.29e-03	1.85e-04	1.51e-04
28_EAML_AD Exclusive	GS_tier1 Exclusive	1.31e-02	8.20e-03	1.01e-03	1.01e-04
GS_tier1 Exclusive	28_EAML_AD Exclusive	1.35e-02	6.84e-04	4.26e-04	2.44e-04
28_EAML_AD Exclusive	Overlap	1.58e-01	1.98e-02	9.90e-02	1.39e-01
GS_tier1 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.32e-04	2.49e-13	6.70e-39	2.05e-19



Evaluating how well 28_EAML_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
28_EAML_AD Exclusive	GS_tier1	0.75	3.39	3.31	3.03	4.92
GS_tier1 Exclusive	28_EAML_AD	0.75	2.18	4.16	2.75	4.47
28_EAML_AD Exclusive	GS_tier1 Exclusive	0.75	3.13	3.33	2.37	4.29
GS_tier1 Exclusive	28_EAML_AD Exclusive	0.74	2.31	3.52	2.72	4.43
28_EAML_AD Exclusive	Overlap	0.94	1.00	-523663530910857.00	0.98	1.59
GS_tier1 Exclusive	Overlap	1.00	1.22	inf	1.71	1.76
Overlap	Exclusives	0.86	inf	8.75	2.67	9.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
28_EAML_AD Exclusive	GS_tier1	0.00	4.79	0.48	0.38	0.49
GS_tier1 Exclusive	28_EAML_AD	0.00	1.91	8.99	6.08	2.35
28_EAML_AD Exclusive	GS_tier1 Exclusive	0.00	3.85	0.52	2.36	4.26
GS_tier1 Exclusive	28_EAML_AD Exclusive	0.00	2.03	6.34	4.01	0.45
28_EAML_AD Exclusive	Overlap	0.00	-0.08	-2101235441941084.75	0.30	1.74
GS_tier1 Exclusive	Overlap	0.02	11.42	151272923003761312.00	95.23	57.76
Overlap	Exclusives	0.02	7680285337446798.00	14.76	8.85	24.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
28_EAML_AD Exclusive	27	27	
GS_tier1 Exclusive	30	29	MS4A
Overlap	1	1