Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
28_EAML_AD	Ismael_GS	4.02e-09	9.77e-11	1.61e-11	1.23e-10
Ismael_GS	28_EAML_AD	5.34e-04	1.18e-04	7.96e-08	2.86e-08



Evaluating how well 28_EAML_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
28_EAML_AD	Ismael_GS	0.93	2.96	6.59	3.21	5.80
Ismael_GS	28_EAML_AD	0.79	3.93	4.87	2.63	5.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
28_EAML_AD	Ismael_GS	0.01	6.40	16.95	7.75	11.96
Ismael_GS	28_EAML_AD	0.01	5.01	4.17	6.05	11.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
28_EAML_AD	28	28	
Ismael_GS	14	14