Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
28_EAML_AD Exclusive	GWAS_GS	5.77e-03	1.12e-02	4.36e-04	1.22e-06
GWAS_GS Exclusive	28_EAML_AD	1.84e-03	4.54e-04	1.08e-04	1.78e-05
28_EAML_AD Exclusive	GWAS_GS Exclusive	1.24e-02	1.12e-02	9.65e-04	1.14e-06
GWAS_GS Exclusive	28_EAML_AD Exclusive	2.10e-03	4.26e-04	2.28e-05	6.05e-05
28_EAML_AD Exclusive	Overlap	1.98e-01	1.98e-02	5.94e-02	1.98e-01
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.29e-04	4.18e-12	1.11e-52	3.93e-18



Evaluating how well 28_EAML_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
28_EAML_AD Exclusive	GWAS_GS	0.66	2.79	3.63	2.94	5.22
GWAS_GS Exclusive	28_EAML_AD	0.75	3.20	3.80	2.77	4.86
28_EAML_AD Exclusive	GWAS_GS Exclusive	0.66	2.92	3.52	2.79	5.69
GWAS_GS Exclusive	28_EAML_AD Exclusive	0.74	3.23	4.59	3.16	4.05
28_EAML_AD Exclusive	Overlap	0.94	0.96	-523663530910857.00	1.06	1.34
GWAS_GS Exclusive	Overlap	1.00	1.13	96906977428865.00	1.16	1.65
Overlap	Exclusives	0.74	147145463844973.34	8.65	2.72	8.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
28_EAML_AD Exclusive	GWAS_GS	0.01	3.41	4.66	2.58	4.28
GWAS_GS Exclusive	28_EAML_AD	0.01	6.12	9.32	9.23	14.35
28_EAML_AD Exclusive	GWAS_GS Exclusive	0.01	2.51	7.26	5.93	9.97
GWAS_GS Exclusive	28_EAML_AD Exclusive	0.00	6.76	8.67	6.60	3.82
28_EAML_AD Exclusive	Overlap	0.00	0.38	-2101235441941084.75	0.62	0.73
GWAS_GS Exclusive	Overlap	0.04	20.97	inf	75.42	170.40
Overlap	Exclusives	0.03	3353271550948659.00	22.90	6.83	16.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
28_EAML_AD Exclusive	27	27	
GWAS_GS Exclusive	108	103	LINC00158;PCDH11Y;D21S2088E;MIR302F;SLC8A1-AS1
Overlap	1	1