Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
20_GeneEmbed_AD	Ismael_GS	3.19e-11	1.53e-09	1.37e-13	6.91e-11
Ismael_GS	20_GeneEmbed_AD	1.83e-04	1.94e-04	7.56e-06	1.71e-10



Evaluating how well 20_GeneEmbed_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
20_GeneEmbed_AD	Ismael_GS	0.94	3.01	5.79	3.40	5.59
Ismael_GS	20_GeneEmbed_AD	0.89	3.39	4.64	2.39	6.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
20_GeneEmbed_AD	Ismael_GS	0.01	4.72	31.45	9.95	18.02
Ismael_GS	20_GeneEmbed_AD	0.01	17.41	16.69	15.14	39.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
20_GeneEmbed_AD	20	20	
Ismael_GS	14	14