Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
20_GeneEmbed_AD Exclusive	GWAS_GS	1.66e-03	1.32e-01	2.36e-05	1.49e-04
GWAS_GS Exclusive	20_GeneEmbed_AD	1.06e-02	4.11e-02	2.90e-03	6.79e-08
20_GeneEmbed_AD Exclusive	GWAS_GS Exclusive	1.72e-03	2.10e-01	2.89e-05	1.93e-04
GWAS_GS Exclusive	20_GeneEmbed_AD Exclusive	8.89e-02	7.98e-02	1.88e-02	4.15e-07
20_GeneEmbed_AD Exclusive	Overlap	2.07e-03	1.03e-02	9.85e-05	1.03e-02
GWAS_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	2.38e-12	6.09e-13	7.86e-31	4.74e-20



Evaluating how well 20_GeneEmbed_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
20_GeneEmbed_AD Exclusive	GWAS_GS	0.63	1.68	2.17	1.39	3.90
GWAS_GS Exclusive	20_GeneEmbed_AD	0.87	1.91	4.45	2.12	5.87
20_GeneEmbed_AD Exclusive	GWAS_GS Exclusive	0.62	1.78	2.27	1.46	4.07
GWAS_GS Exclusive	20_GeneEmbed_AD Exclusive	0.85	1.67	3.26	2.11	5.26
20_GeneEmbed_AD Exclusive	Overlap	0.96	1.74	1.79	1.98	2.06
GWAS_GS Exclusive	Overlap	1.00	2.30	2.02	1.92	2.29
Overlap	Exclusives	0.76	2.76	8.29	2.72	9.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
20_GeneEmbed_AD Exclusive	GWAS_GS	0.01	1.88	2.38	1.68	1.63
GWAS_GS Exclusive	20_GeneEmbed_AD	0.02	5.31	14.48	11.48	2.92
20_GeneEmbed_AD Exclusive	GWAS_GS Exclusive	0.01	2.10	2.40	2.17	3.57
GWAS_GS Exclusive	20_GeneEmbed_AD Exclusive	0.01	0.63	2.99	3.13	13.68
20_GeneEmbed_AD Exclusive	Overlap	0.00	0.58	2.68	4.26	3.04
GWAS_GS Exclusive	Overlap	0.08	164.30	163.48	61.12	273.84
Overlap	Exclusives	0.06	25.41	68.99	22.56	78.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
20_GeneEmbed_AD Exclusive	18	18	
GWAS_GS Exclusive	107	102	LINC00158;SLC8A1-AS1;MIR302F;PCDH11Y;D21S2088E
Overlap	2	2