Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7_EPI_AD Exclusive	GS_tier1	7.19e-03	4.45e-04	1.98e-08	1.41e-06
GS_tier1 Exclusive	7_EPI_AD	3.85e-02	1.14e-01	4.47e-03	4.47e-03
7_EPI_AD Exclusive	GS_tier1 Exclusive	3.13e-03	6.37e-04	1.22e-10	1.49e-06
GS_tier1 Exclusive	7_EPI_AD Exclusive	7.15e-02	9.69e-02	2.90e-02	2.53e-02
7_EPI_AD Exclusive	Overlap	3.96e-02	1.98e-02	3.96e-02	2.18e-01
GS_tier1 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	5.01e-09	5.13e-14	1.07e-24	5.38e-16



Evaluating how well 7_EPI_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD Exclusive	GS_tier1	0.74	2.87	4.13	1.39	4.95
GS_tier1 Exclusive	7_EPI_AD	0.86	0.95	2.67	1.69	2.96
7_EPI_AD Exclusive	GS_tier1 Exclusive	0.74	2.76	4.44	1.62	4.32
GS_tier1 Exclusive	7_EPI_AD Exclusive	0.84	1.07	2.51	1.11	2.66
7_EPI_AD Exclusive	Overlap	0.95	1.57	412699929653024.50	1.35	1.42
GS_tier1 Exclusive	Overlap	1.00	1.20	inf	1.57	1.70
Overlap	Exclusives	0.90	1471650376326195.00	8.32	2.43	8.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD Exclusive	GS_tier1	0.00	4.82	2.29	2.08	0.58
GS_tier1 Exclusive	7_EPI_AD	0.01	5.15	10.70	9.38	15.99
7_EPI_AD Exclusive	GS_tier1 Exclusive	0.00	5.56	1.33	1.16	3.18
GS_tier1 Exclusive	7_EPI_AD Exclusive	0.00	2.76	5.52	2.34	4.09
7_EPI_AD Exclusive	Overlap	0.00	1.38	11728170351236742.00	1.13	0.01
GS_tier1 Exclusive	Overlap	0.02	23.80	151272923003761312.00	63.34	2.64
Overlap	Exclusives	0.03	inf	40.32	1.90	8.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7_EPI_AD Exclusive	6	6	
GS_tier1 Exclusive	30	29	MS4A
Overlap	1	1