Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7_EPI_AD	GS_tier2	9.20e-03	9.11e-03	5.55e-08	7.01e-04
GS_tier2	7_EPI_AD	2.11e-02	1.21e-01	2.45e-03	2.29e-03



Evaluating how well 7_EPI_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD	GS_tier2	0.70	0.97	3.41	1.90	4.80
GS_tier2	7_EPI_AD	0.86	1.36	1.93	1.29	3.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD	GS_tier2	0.01	1.14	5.31	0.70	1.02
GS_tier2	7_EPI_AD	0.01	5.12	2.40	12.58	14.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7_EPI_AD	7	7	
GS_tier2	46	43	IGH;TNSF13;TNSF12