Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7_EPI_AD	Ismael_GS	1.57e-07	1.24e-07	6.83e-08	2.59e-07
Ismael_GS	7_EPI_AD	5.59e-04	2.70e-03	6.51e-04	9.06e-04



Evaluating how well 7_EPI_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD	Ismael_GS	0.91	2.06	5.67	2.37	5.30
Ismael_GS	7_EPI_AD	0.89	2.39	3.66	1.75	3.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD	Ismael_GS	0.01	8.02	7.01	3.77	2.85
Ismael_GS	7_EPI_AD	0.01	14.12	16.90	6.78	26.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7_EPI_AD	7	7	
Ismael_GS	14	14