Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
7_EPI_AD Exclusive	GWAS_GS	9.94e-02	1.01e-03	1.85e-15	8.68e-09
GWAS_GS Exclusive	7_EPI_AD	7.89e-02	4.45e-01	1.64e-02	5.36e-03
7_EPI_AD Exclusive	GWAS_GS Exclusive	1.64e-01	8.79e-04	4.38e-15	2.25e-08
GWAS_GS Exclusive	7_EPI_AD Exclusive	1.85e-01	2.92e-01	5.43e-02	2.15e-02
7_EPI_AD Exclusive	Overlap	1.98e-02	1.98e-02	5.94e-02	9.90e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.07e-04	1.37e-08	2.52e-40	6.06e-14



Evaluating how well 7_EPI_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD Exclusive	GWAS_GS	0.66	1.94	4.24	1.66	5.17
GWAS_GS Exclusive	7_EPI_AD	0.84	0.91	1.53	0.87	2.89
7_EPI_AD Exclusive	GWAS_GS Exclusive	0.65	1.97	3.60	1.53	4.74
GWAS_GS Exclusive	7_EPI_AD Exclusive	0.82	0.76	1.68	0.60	3.23
7_EPI_AD Exclusive	Overlap	0.95	1.83	412699929653024.50	1.45	1.80
GWAS_GS Exclusive	Overlap	1.00	1.32	96906977428865.00	1.15	1.69
Overlap	Exclusives	0.73	313480999921680.00	7.22	2.75	9.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
7_EPI_AD Exclusive	GWAS_GS	0.01	2.16	3.56	1.27	3.99
GWAS_GS Exclusive	7_EPI_AD	0.01	11.03	13.53	10.25	11.72
7_EPI_AD Exclusive	GWAS_GS Exclusive	0.01	2.28	2.69	0.71	2.24
GWAS_GS Exclusive	7_EPI_AD Exclusive	0.00	1.33	4.12	1.40	6.50
7_EPI_AD Exclusive	Overlap	0.00	4.04	11728170351236742.00	0.83	0.09
GWAS_GS Exclusive	Overlap	0.04	30.22	inf	58.75	66.56
Overlap	Exclusives	0.02	8799056478798768.00	26.26	10.59	31.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
7_EPI_AD Exclusive	6	6	
GWAS_GS Exclusive	108	103	D21S2088E;LINC00158;MIR302F;SLC8A1-AS1;PCDH11Y
Overlap	1	1