Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_All_variants_unique	TIER1_GS	2.88e-02	4.16e-02	2.02e-02	2.46e-01
TIER1_GS	Sigma_All_variants_unique	1.07e-01	4.71e-01	6.70e-01	3.19e-01



Evaluating how well Sigma_All_variants_unique genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_All_variants_unique	TIER1_GS	0.49	-1.45	-2.77	-1.52	-0.08
TIER1_GS	Sigma_All_variants_unique	0.47	-0.58	-0.11	-0.39	-0.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_All_variants_unique	TIER1_GS	0.00	-0.95	-2.09	-0.46	-0.46
TIER1_GS	Sigma_All_variants_unique	0.00	-0.31	-0.84	-0.82	-0.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_All_variants_unique	43	41	MRPL23;ZNF511-PRAP1
TIER1_GS	31	30	MS4A