Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_EPI_AD Exclusive	GWAS_GS	2.31e-03	1.88e-02	2.80e-06	4.05e-04
GWAS_GS Exclusive	100_EPI_AD	1.51e-02	2.67e-03	2.06e-05	2.35e-07
100_EPI_AD Exclusive	GWAS_GS Exclusive	2.52e-03	3.71e-02	1.84e-05	6.73e-04
GWAS_GS Exclusive	100_EPI_AD Exclusive	1.60e-02	3.20e-03	4.79e-05	8.51e-06
100_EPI_AD Exclusive	Overlap	3.86e-01	5.17e-01	3.46e-02	3.72e-02
GWAS_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	4.17e-04	1.93e-10	6.89e-62	9.97e-23



Evaluating how well 100_EPI_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EPI_AD Exclusive	GWAS_GS	0.63	1.53	2.72	1.74	4.52
GWAS_GS Exclusive	100_EPI_AD	0.68	2.22	4.18	2.70	6.88
100_EPI_AD Exclusive	GWAS_GS Exclusive	0.62	1.85	2.60	1.73	4.32
GWAS_GS Exclusive	100_EPI_AD Exclusive	0.67	2.30	3.65	2.42	5.55
100_EPI_AD Exclusive	Overlap	0.94	1.16	2.32	1.73	2.28
GWAS_GS Exclusive	Overlap	1.00	1.81	1.81	2.21	2.43
Overlap	Exclusives	0.73	8.20	12.05	2.66	10.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EPI_AD Exclusive	GWAS_GS	0.01	3.62	3.48	2.35	4.26
GWAS_GS Exclusive	100_EPI_AD	0.01	4.81	10.15	6.89	7.28
100_EPI_AD Exclusive	GWAS_GS Exclusive	0.01	3.59	3.29	2.85	3.15
GWAS_GS Exclusive	100_EPI_AD Exclusive	0.01	3.70	5.66	4.39	4.64
100_EPI_AD Exclusive	Overlap	0.01	7.17	28.76	20.90	19.84
GWAS_GS Exclusive	Overlap	0.07	74.93	623.34	108.26	10.94
Overlap	Exclusives	0.06	74.39	73.33	13.94	58.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_EPI_AD Exclusive	98	98	
GWAS_GS Exclusive	107	102	PCDH11Y;LINC00158;SLC8A1-AS1;D21S2088E;MIR302F
Overlap	2	2