Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_EPI_AD	Ismael_GS	1.51e-07	2.51e-10	3.39e-11	2.80e-10
Ismael_GS	100_EPI_AD	2.25e-08	1.13e-07	4.86e-13	2.14e-13



Evaluating how well 100_EPI_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EPI_AD	Ismael_GS	0.94	2.37	6.36	3.21	7.17
Ismael_GS	100_EPI_AD	0.75	5.32	6.95	4.19	9.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EPI_AD	Ismael_GS	0.03	11.36	126.77	38.86	81.46
Ismael_GS	100_EPI_AD	0.02	15.90	11.32	12.51	23.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_EPI_AD	100	100	
Ismael_GS	14	14