Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_EPI_AD	GS_tier2	3.07e-03	3.59e-03	2.04e-05	3.66e-05
GS_tier2	100_EPI_AD	3.52e-07	1.35e-07	5.19e-12	5.35e-12



Evaluating how well 100_EPI_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EPI_AD	GS_tier2	0.73	3.10	4.62	3.24	5.59
GS_tier2	100_EPI_AD	0.73	5.10	7.04	3.57	7.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EPI_AD	GS_tier2	0.01	2.11	12.33	10.57	24.48
GS_tier2	100_EPI_AD	0.02	14.05	18.43	8.88	10.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_EPI_AD	100	100	
GS_tier2	46	43	TNSF12;IGH;TNSF13