Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_GeneEmbed_AD	Ismael_GS	6.93e-05	9.61e-05	4.07e-10	2.69e-07
Ismael_GS	100_GeneEmbed_AD	4.58e-06	2.19e-08	1.36e-13	1.80e-21



Evaluating how well 100_GeneEmbed_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_GeneEmbed_AD	Ismael_GS	0.90	4.05	4.72	2.50	5.84
Ismael_GS	100_GeneEmbed_AD	0.80	2.70	7.07	2.22	11.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_GeneEmbed_AD	Ismael_GS	0.00	3.92	12.31	5.17	11.54
Ismael_GS	100_GeneEmbed_AD	0.02	6.35	15.53	5.74	22.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_GeneEmbed_AD	100	99	SIGLEC5
Ismael_GS	14	14